Ventricles as a major site of atrial natriuretic factor synthesis and release in cardiomyopathic hamsters with heart failure.
作者： G Thibault , M Nemer , J Drouin , J P Lavigne , J Ding
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摘要: The aim of the present study was to correlate in cardiomyopathic hamsters with congestive heart failure levels atrial and ventricular natriuretic factor (ANF) messenger RNA (mRNA) immunoreactive ANF (IR-ANF) plasma relative amount IR-ANF released by whole versus isolated ventricles Langendorff preparation. High-performance liquid chromatography analysis forms effluent also performed. As previously found for cardiac IR-ANF, mRNA decreased gradually atria increased an analogous fashion severity failure. Plasma (C-terminal) were more elevated moderate than severe failure, as heart. On contrary, from animals yielded that Thus, while controls contributed 35.8% heart, 17.5%, those 73.9%. These results indicate cardiocytes contribute their counterpart are a major source Analysis hearts revealed propeptide (and its cleaved products) circulation hamsters. suggest synthesis secretion do not increase conjointly but during
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