Ischemia stimulates the release of atrial natriuretic peptide from rat cardiac ventricular myocardium in vitro
作者： Paavo A. Uusimaa , Keijo J. Peuhkurinen , Ilmo E. Hassinen , Olli Vuolteenaho , Heikki Ruskoaho
DOI: 10.1016/0024-3205(92)90438-U
关键词:
摘要: Abstract The effect of ischemia on atrial natriuretic peptide (ANP) release from heart ventricles was studied by exposing the perfused hearts Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats to global after excision atria. Ischemia for 2, 5 20 min caused an increase 0.3 ± 1.1, 12.4 5.5 11.4 4.2 ng/g dry weight in ANP WKY ventricles, respectively. increased 3.4 2.8 minutes' SHR ventricles. not cell damage, as only processed form detected perfusates. correlated positively with tissue lactate/pyruvate ratio (r=0.85) adenosine (r=0.99), negatively phosphorylation potential (r=0.70). results indicate that ventricular increases release, probably due changes myocardial energy metabolism.
elsevier.com
sci-hub.se 参考文章(38)
J C Louis, E Magal, E Yavin, Protein kinase C alterations in the fetal rat brain after global ischemia. Journal of Biological Chemistry. ,vol. 263, pp. 19282- 19285 ,(1988) , 10.1016/S0021-9258(19)77631-5
B. M. Brenner, B. J. Ballermann, M. E. Gunning, M. L. Zeidel, Diverse biological actions of atrial natriuretic peptide Physiological Reviews. ,vol. 70, pp. 665- 699 ,(1990) , 10.1152/PHYSREV.1990.70.3.665
Hiroaki Matsubara, Mitsushige Nishikawa, Yukihisa Umeda, Tomomichi Taniguchi, Toshiji Iwasaka, Toru Kurimoto, Yoko Yamane, Mitsuo Inada, The role of atrial pressure in secreting atrial natriuretic polypeptides American Heart Journal. ,vol. 113, pp. 1457- 1463 ,(1987) , 10.1016/0002-8703(87)90662-4
G Thibault, M Nemer, J Drouin, J P Lavigne, J Ding, C Charbonneau, R Garcia, J Genest, G Jasmin, M Sole, Ventricles as a major site of atrial natriuretic factor synthesis and release in cardiomyopathic hamsters with heart failure. Circulation Research. ,vol. 65, pp. 71- 82 ,(1989) , 10.1161/01.RES.65.1.71
Randall C. Starling, Thomas M. O'Dorisio, Robert J. cody, Rapid reduction but lack of normalization of atrial natriuretic peptide levels in patients with congestive heart failure after cardiac transplantation American Heart Journal. ,vol. 122, pp. 258- 261 ,(1991) , 10.1016/0002-8703(91)90795-J
C Steenbergen, M L Hill, R B Jennings, Volume regulation and plasma membrane injury in aerobic, anaerobic, and ischemic myocardium in vitro. Effects of osmotic cell swelling on plasma membrane integrity. Circulation Research. ,vol. 57, pp. 864- 875 ,(1985) , 10.1161/01.RES.57.6.864
R. E. Lang, H. Thölken, D. Ganten, F. C. Luft, H. Ruskoaho, Th. Unger, Atrial natriuretic factor—a circulating hormone stimulated by volume loading Nature. ,vol. 314, pp. 264- 266 ,(1985) , 10.1038/314264A0
Benjamin D. Robalino, Richard W. Petrella, Fuad Y. Jubran, Emmanuel L. Bravo, Bernadine P. Healy, Patrick L. Whitlow, Atrial natriuretic factor in patients with right ventricular infarction Journal of the American College of Cardiology. ,vol. 15, pp. 546- 553 ,(1990) , 10.1016/0735-1097(90)90623-W
L H E H SNOECKX, G J VAN DER VUSSE, W A COUMANS, P H M WILLEMSEN, T VAN DER NAGEL, R S RENEMAN, Myocardial function in normal and spontaneously hypertensive rats during reperfusion after a period of global ischaemia Cardiovascular Research. ,vol. 20, pp. 67- 75 ,(1986) , 10.1093/CVR/20.1.67
Olli Vuolteenaho, Olli Arjamaa, Nicholas Ling, Atrial natriuretic polypeptides (ANP): Rat atria store high molecular weight precursor but secrete processed peptides of 25–35 amino acids Biochemical and Biophysical Research Communications. ,vol. 129, pp. 82- 88 ,(1985) , 10.1016/0006-291X(85)91406-8