Experimental models to study cell wounding and repair.

作者: Hewan Belete , Lindsay Godin , Randolph Stroetz , Rolf Hubmayr

DOI: 10.1159/000272052

关键词: CellDNA repairCell biologyElectroporationBiologyLesionVentilator-associated lung injuryCell membraneCell typeLung injuryPathology

摘要: Cell wounding, that is a loss of plasma membrane integrity, common everyday occurrence in load bearing organs such as muscle, skin, and bone. In general, these injuries trigger adaptive responses to either restore homeostasis or protect the cells from further damage. The ability integrity after injury critical for cell survival all possess means do so. However, probability wound repair depends on type, well size nature lesion. Several vitro experimental models have been developed simulate specific stresses experience vivo. Motivated by our interest studying mechanisms relevant ventilator associated lung injury, we review some most frequently used wounding present new data pertaining alveolar epithelium.

参考文章(66)
G TERHAAR, Therapeutic applications of ultrasound. Progress in Biophysics & Molecular Biology. ,vol. 93, pp. 111- 129 ,(2007) , 10.1016/J.PBIOMOLBIO.2006.07.005
C Baitinger, J Alderton, M Poenie, H Schulman, R A Steinhardt, Multifunctional Ca2+/calmodulin-dependent protein kinase is necessary for nuclear envelope breakdown. Journal of Cell Biology. ,vol. 111, pp. 1763- 1773 ,(1990) , 10.1083/JCB.111.5.1763
J. B. West, K. Tsukimoto, O. Mathieu-Costello, R. Prediletto, Stress failure in pulmonary capillaries Journal of Applied Physiology. ,vol. 70, pp. 1731- 1742 ,(1991) , 10.1152/JAPPL.1991.70.4.1731
K. Tsukimoto, O. Mathieu-Costello, R. Prediletto, A. R. Elliott, J. B. West, Ultrastructural appearances of pulmonary capillaries at high transmural pressures Journal of Applied Physiology. ,vol. 71, pp. 573- 582 ,(1991) , 10.1152/JAPPL.1991.71.2.573
K Miyake, P L McNeil, Vesicle accumulation and exocytosis at sites of plasma membrane disruption. Journal of Cell Biology. ,vol. 131, pp. 1737- 1745 ,(1995) , 10.1083/JCB.131.6.1737
Mingyao Liu, A. Keith Tanswell, Martin Post, Mechanical force-induced signal transduction in lung cells. American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 277, ,(1999) , 10.1152/AJPLUNG.1999.277.4.L667
Albert J. Banes, Jerome Gilbert, Duane Taylor, Olivier Monbureau, A new vacuum-operated stress-providing instrument that applies static or variable duration cyclic tension or compression to cells in vitro Journal of Cell Science. ,vol. 75, pp. 35- 42 ,(1985) , 10.1242/JCS.75.1.35
Bastien D. Gomperts, Peter E. R. Tatham, Rat mast cells degranulate in response to microinjection of guanine nucleotide. Journal of Cell Science. ,vol. 98, pp. 217- 224 ,(1991) , 10.1242/JCS.98.2.217
David E. Goldman, POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES The Journal of General Physiology. ,vol. 27, pp. 37- 60 ,(1943) , 10.1085/JGP.27.1.37