Cease-fire at the leading edge: new perspectives on actin filament branching, debranching, and cross-linking.
作者： Casey A. Ydenberg , Benjamin A. Smith , Dennis Breitsprecher , Jeff Gelles , Bruce L. Goode
DOI: 10.1002/CM.20543
关键词: Actin filament branching 、 Biophysics 、 Formins 、 MDia1 、 Actin remodeling of neurons 、 Actin remodeling 、 Biology 、 Lamellipodium 、 Actin cytoskeleton 、 Arp2/3 complex 、 Cell biology
摘要: Membrane protrusion at the leading edge of migrating cells is driven by polymerization actin. Recent studies using advanced imaging techniques raised a lively controversy about morphology these filaments; however, common ground between two sides now appears to have been found. Here we discuss how has led deeper consideration architecture actin networks underlying cell migration, and helped define new challenges that lie ahead.
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