High Melatonin Concentrations in Third Ventricular Cerebrospinal Fluid Are Not due to Galen Vein Blood Recirculating through the Choroid Plexus

摘要: Melatonin has been implicated in several neurotropic effects, but few studies have investigated the bioavailability of melatonin brain. The discovery periventricular sites action adjacent to third ventricle forced us investigate dynamics cerebrospinal fluid (CSF) release and source this melatonin. Our first study demonstrated unequivocally that CSF melatonin, like jugular plasma accurately reflects duration night is rapidly suppressed by light. However, levels are 20-fold higher than nocturnal concentrations. A further showed increased before CSF, raising possibility taken up from blood after recirculation through Galen vein. a final experiment suggested strongly released directly into ventricle, as lateral were 7-fold lower those...