OKT3 monoclonal antibodies induce interleukin-6 and interleukin-10: a possible cause of lymphoproliferative disorders associated with transplantation.

摘要: The risk of posttransplantation lymphoproliferative disorder (PTLD) has increased with the use new, highly potent immunosuppressive agents. Monoclonal anti-T-cell antibodies such as OKT3 have been associated a particularly high these frequently fatal Epstein-Barr virus (EBV)-related B-cell neoplasms. is powerful mitogen, raising possibility that T-cell activation and cytokine release may facilitate development PTLD. Interleukin-6 interleukin-10 recently shown to play major roles in neoplasia general, EBV-induced transformation outgrowth. PTLD after treatment might be mediated by those cytokines. On other hand, OKT3-related simply result profound depletion induced drug, mechanisms for lymphomagenesis no different than operative PTLDs arising immunosuppressed patients. A clearer understanding relevant will require further work vivo models disease significant implications design new