Remission of posttransplant lymphoproliferative disorder after interferon alfa therapy.

摘要: Posttransplant lymphoproliferative disorder (PTLD) is one of the major complications immunosuppressive therapy. PTLD strongly associated with Epstein-Barr virus (EBV). It believed that EBV-infected B cells proliferate in an unchecked manner due to suppression cytotoxic T and elevation cell-promoting cytokines. There no consensus on treatment other than reduction We report a case monoclonal confined lymph nodes. The patient did not initially respond immunosuppression, oral acyclovir, intravenous immunoglobulin injection. She subsequently responded when subcutaneous injections interferon alfa (5 million U) were given three times week. received 3-mo course remained remission 12 mo after treatment. Her graft function was well maintained, cyclosporin A restarted 2 achieving remission. clinical manifestations, risk factors, pathogenesis, PTLD, as previously reported cases treated interferon, reviewed. On basis results presented here, it appears may be useful treating there need for further trials.