Epstein–Barr virus and post-transplant lymphoproliferative disease

摘要: There is convincing evidence that Epstein-Barr virus (EBV) associated with post-transplant lymphoproliferative disease (PTLD). Primary EBV infection following transplantation occurs in as many 90% of cases PTLD children and pretransplant seronegativity a recognized risk factor for developing PTLD. Other factors include young age at the time transplant, type transplant recipient receives intensity immunosuppression. The clinical presentation often nonspecific tissue biopsy necessary to establish diagnosis. appears be correlation between viral load measured by polymerase chain reaction (PCR) peripheral blood quantitative PCR may useful guide management Antiviral drugs cytomegalovirus-immunoglobulin G have role preventing Because results from functional over-immunosuppression, initial treatment reduction agents, interferon, immuno-based monoclonal therapy, cell-based therapy chemotherapy also potential treating this disorder. At present there no standardized approach evaluation