Circular RNAs Regulate Cancer Onset and Progression via Wnt/β-Catenin Signaling Pathway
作者： Yun-Feng Li , Jian Zhang , Lei Yu
DOI: 10.3349/YMJ.2019.60.12.1117
关键词: Carcinogenesis 、 Cancer research 、 Cancer development 、 Diagnostic biomarker 、 Circular RNA 、 Signal transduction 、 Wnt signaling pathway 、 Biology 、 Cancer 、 Wnt β catenin signaling
摘要: Cancer remains to be a major challenge for public health providers, and is the second leading cause of death worldwide. Therefore, it imperative explore mechanisms underlying cancer initiation development, design novel diagnostics therapeutics. Circular RNAs (circRNAs), which exhibit covalently closed loop structure, are involved in variety diseases, including cancer. The aberrant expression circRNAs contributes development various cancers by disrupting interplay specific signaling pathways, Wnt/β-catenin pathway, controls plethora cellular processes that drive development. interactions between (specifically expressed different tissues) pathway presents potential diagnostic biomarkers therapeutic targets. In this review, we have summarized research discoveries on functions pathway-related modulation oncogenesis progression types We anticipate our findings will contribute improvement or circRNAs-based strategies treatment.
sci-hub.st 参考文章(95)
Guanli Huang, Hua Zhu, Yixiong Shi, Wenzhi Wu, Huajie Cai, Xiangjian Chen, cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/β-catenin pathway. PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0131225
Akira Kikuchi, Hideki Yamamoto, Akira Sato, Shinji Matsumoto, New insights into the mechanism of Wnt signaling pathway activation. International Review of Cell and Molecular Biology. ,vol. 291, pp. 21- 71 ,(2011) , 10.1016/B978-0-12-386035-4.00002-1
Fang Li, Liyuan Zhang, Wei Li, Jieqiong Deng, Jian Zheng, Mingxing An, Jiachun Lu, Yifeng Zhou, Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway Oncotarget. ,vol. 6, pp. 6001- 6013 ,(2015) , 10.18632/ONCOTARGET.3469
Xiaowen Song, Na Xin, Wei Wang, Chenghai Zhao, Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis. Oncotarget. ,vol. 6, pp. 35579- 35588 ,(2015) , 10.18632/ONCOTARGET.5758
Jamie N. Anastas, Randall T. Moon, WNT signalling pathways as therapeutic targets in cancer Nature Reviews Cancer. ,vol. 13, pp. 11- 26 ,(2013) , 10.1038/NRC3419
Suping Zhang, Liguang Chen, Bing Cui, Han-Yu Chuang, Jianqiang Yu, Jessica Wang-Rodriguez, Li Tang, George Chen, Grzegorz W. Basak, Thomas J. Kipps, ROR1 Is Expressed in Human Breast Cancer and Associated with Enhanced Tumor-Cell Growth PLoS ONE. ,vol. 7, pp. e31127- ,(2012) , 10.1371/JOURNAL.PONE.0031127
Riccardo Fodde, Thomas Brabletz, Wnt/β-catenin signaling in cancer stemness and malignant behavior Current Opinion in Cell Biology. ,vol. 19, pp. 150- 158 ,(2007) , 10.1016/J.CEB.2007.02.007
Amanda Nickles Fader, Lucybeth Nieves Arriba, Heidi E. Frasure, Vivian E. von Gruenigen, Endometrial cancer and obesity: epidemiology, biomarkers, prevention and survivorship. Gynecologic Oncology. ,vol. 114, pp. 121- 127 ,(2009) , 10.1016/J.YGYNO.2009.03.039
Hans Clevers, Roel Nusse, Wnt/β-catenin signaling and disease. Cell. ,vol. 149, pp. 1192- 1205 ,(2012) , 10.1016/J.CELL.2012.05.012
Thorsten Zenz, Daniel Mertens, Ralf Küppers, Hartmut Döhner, Stephan Stilgenbauer, From pathogenesis to treatment of chronic lymphocytic leukaemia Nature Reviews Cancer. ,vol. 10, pp. 37- 50 ,(2010) , 10.1038/NRC2764