From pathogenesis to treatment of chronic lymphocytic leukaemia
作者： Thorsten Zenz , Daniel Mertens , Ralf Küppers , Hartmut Döhner , Stephan Stilgenbauer
DOI: 10.1038/NRC2764
关键词:
摘要: Chronic lymphocytic leukaemia (CLL) has several unique features that distinguish it from other cancers. Most CLL tumour cells are inert and arrested in G0/G1 of the cell cycle there is only a small proliferative compartment; however, progressive accumulation malignant will ultimately lead to symptomatic disease. Pathogenic mechanisms have been elucidated involve multiple external (for example, microenvironmental stimuli antigenic drive) internal (genetic epigenetic) events crucial transformation, progression evolution CLL. Our growing understanding biology allowing translation targets biological classifiers into clinical practice.
nature.com
sci-hub.se 参考文章(153)
Rosa Catera, Gregg J. Silverman, Katerina Hatzi, Till Seiler, Sebastien Didier, Lu Zhang, Maxime Hervé, Eric Meffre, David G. Oscier, Helen Vlassara, R. Hal Scofield, Yifang Chen, Steven L. Allen, Jonathan Kolitz, Kanti R. Rai, Charles C. Chu, Nicholas Chiorazzi, Chronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Oxidation Molecular Medicine. ,vol. 14, pp. 665- 674 ,(2008) , 10.2119/2008-00102.CATERA
Claudia Schaffner, Stephan Stilgenbauer, Gudrun A. Rappold, Hartmut Döhner, Peter Lichter, Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia. Blood. ,vol. 94, pp. 748- 753 ,(1999) , 10.1182/BLOOD.V94.2.748.414K02_748_753
Irene M. Pedersen, Shinichi Kitada, Lorenzo M. Leoni, Juan M. Zapata, James G. Karras, Nobuhiro Tsukada, Thomas J. Kipps, Yong Sung Choi, Frank Bennett, John C. Reed, Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1. Blood. ,vol. 100, pp. 1795- 1801 ,(2002) , 10.1182/BLOOD.V100.5.1795.H81702001795_1795_1801
I. Förster, H. Gu, K. Rajewsky, Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment. The EMBO Journal. ,vol. 7, pp. 3693- 3703 ,(1988) , 10.1002/J.1460-2075.1988.TB03251.X
P. Ghia, P. Circosta, C. Scielzo, A. Vallario, A. Camporeale, L. Granziero, F. Caligaris-Cappio, Differential effects on CLL cell survival exerted by different microenvironmental elements. Current Topics in Microbiology and Immunology. ,vol. 294, pp. 135- 145 ,(2005) , 10.1007/3-540-29933-5_8
Hartmut Dohner, Konstanze Fischer, Martin Bentz, Katrin Hansen, Axel Benner, Georges Cabot, Daniela Diehl, Richard Schlenk, Johannes Coy, Stephan Stilgenbauer, Martin Volkmann, Peter R Galle, Annemarie Poustka, Werner Hunstein, Peter Lichter, p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias Blood. ,vol. 85, pp. 1580- 1589 ,(1995) , 10.1182/BLOOD.V85.6.1580.BLOODJOURNAL8561580
KR Rai, A Sawitsky, EP Cronkite, AD Chanana, RN Levy, BS Pasternack, Clinical staging of chronic lymphocytic leukemia. Blood. ,vol. 46, pp. 219- 234 ,(1975) , 10.1182/BLOOD.V46.2.219.219
U. Klein, R. Dalla-Favera, New Insights into the Phenotype and Cell Derivation of B Cell Chronic Lymphocytic Leukemia Current Topics in Microbiology and Immunology. ,vol. 294, pp. 31- 49 ,(2005) , 10.1007/3-540-29933-5_3
Stuart M. Lichtman, Philip Schulman, Vincent P. Vinciguerra, Kanti R. Rai, Manlio Ferrarini, Nicholas Chiorazzi, Rajendra N. Damle, Tarun Wasil, Franco Fais, Fabio Ghiotto, Angelo Valetto, Steven L. Allen, Aby Buchbinder, Daniel Budman, Klaus Dittmar, Jonathan Kolitz, Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. ,vol. 94, pp. 1840- 1847 ,(1999) , 10.1182/BLOOD.V94.6.1840
Terry J. Hamblin, Zadie Davis, Anne Gardiner, David G. Oscier, Freda K. Stevenson, Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. ,vol. 94, pp. 1848- 1854 ,(1999) , 10.1182/BLOOD.V94.6.1848