Induction of anti foot and mouth disease virus T and B cell responses in cattle immunized with a peptide representing ten amino acids of VP1
作者： P.I. Zamorano , A. Wigdorovitz , D.M. Pérez Filgueira , J.M. Escribano , A.M. Sadir
DOI: 10.1016/S0264-410X(97)00244-2
关键词: Neutralizing antibody 、 Epitope 、 Antigen 、 Virology 、 Antibody 、 Biology 、 Immunodominance 、 Immunogenicity 、 Peptide sequence 、 Epitope mapping 、 Public Health, Environmental and Occupational Health 、 General Immunology and Microbiology 、 Molecular medicine 、 General Veterinary 、 Infectious Diseases
摘要: We previously demonstrated that the immunization of cattle with a synthetic peptide representing amino acid sequence foot and mouth disease virus (FMDV) type O1 Campos VP1 residues 135-160 (p135-160), containing immunodominant T B epitopes, was able to induce strong neutralizing antibody (NA) response. The epitope mapping p135-160 identified epitopes in area restricted 135-144 (Zamorano et al. 1994, Virology 201; 1995, 212). are now reporting that, although covering acids (p135-144) failed elicit an anti-FMDV response, tandem duplication (p135-144 x 2) very efficient inducing NA response cattle. Both cell responses elicited by p135-144 2 were highly specific for since no reactivity detected against peptides 140-160 VP1. Additionally, both long lasting immunized These results constitute good example improvement immune rational handling precisely epitopes. To our knowledge, this is shortest native significant FMDV
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