Influenza Outbreaks in Nursing Homes: How Effective Is Influenza Vaccine in the Institutionalized Elderly?
作者： James F. Jekel , Matthew L. Cartter , Philip O. Renzullo , Steven D. Helgerson , Stanley M. Martin
DOI: 10.1086/646214
关键词: Outbreak 、 Nursing 、 Influenza vaccine 、 Demography 、 Medicine 、 Nursing homes 、 Live attenuated influenza vaccine 、 Confidence interval 、 Relative risk 、 Vaccination 、 Titer 、 Microbiology (medical) 、 Epidemiology 、 Infectious Diseases
摘要: During the 1984-1985 influenza season, outbreaks of A (H3N2) occurred in three Connecticut nursing homes. Influenza vaccination rates were 67% (96 out 144), 35% (30 85) and 69% (332 483), respectively. The relative risk illness for vaccinated compared to unvaccinated residents was 1.8 (95% confidence interval, 0.6, 5.9), 1.6 0.8, 3.0) 1.1 1.7) each homes, In third outbreak, 22 without clinical had a geometric mean titer hemagglutination-inhibition (HI) antibody 20. Although low, this significantly higher than that nine (12, p less .05); only (14%) HI titers greater or equal 40. These results suggest levels not protective at time four five months after vaccination. general, study vaccine effectiveness homes is limited by sample size statistical power. Despite these limits, retrospective investigation often practical way evaluate elderly on yearly basis.
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