Epigallocatechin-3-Gallate Reduces Cytotoxic Effects Caused by Dental Monomers: A Hypothesis
作者： Yang Jiao , Sai Ma , Yirong Wang , Jing Li , Lequn Shan
DOI: 10.12659/MSM.895628
关键词: Oxidative phosphorylation 、 Oxidative stress 、 Apoptosis 、 Cytotoxicity 、 Chemistry 、 Biochemistry 、 Glutathione 、 Redox 、 Intracellular 、 Reactive oxygen species
摘要: Resin monomers from dental composite materials leached due to incomplete polymerization or biodegradation may cause contact allergies and damage pulp. The cytotoxicity of resin is a disturbance intracellular redox equilibrium, characterized by an overproduction reactive oxygen species (ROS) depletion reduced glutathione (GSH). Oxidative stress caused leads the vital cell functions induction apoptosis in affected cells. nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway plays key role cellular defense system against oxidative electrophilic stress. Epigallocatechin-3-gallate (EGCG) can activate Nrf2 induce expression multitude antioxidants phase II enzymes that restore homeostasis. Therefore, here, we tested hypothesis EGCG-mediated protection monomer mediated activation pathway. This study will help elucidate mechanism provide information be helpful improving biocompatibility materials.
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