Regulation of centromeric heterochromatin in the cell cycle by phosphorylation of histone H3 tyrosine 41

摘要: Constitutive heterochromatin packages long stretches of repetitive DNA sequences at the centromere and telomere, ensures genomic integrity these loci by preventing aberrant recombination transcription. The chromatin scaffold is dynamically regulated in cell cycle, inheritance epigenetically silenced state dependent on a transcriptional event imposed underlying non-coding RNA conjunction with replicative phase. Heterochromatin becomes transiently loosened response to reduction binding Swi6, protein, this allows polymerase II access sequence. derived transcripts, turn, drive formation via recruitment other silencing factors. It remains unclear how decompacted cycle-specific manner. Here, we describe mechanism decompaction initiated novel histone modification, H3 tyrosine 41 phosphorylation (H3Y41p). We will discuss H3Y41p cooperates regulatory pathways enforce cycle-dependent regulation constitutive heterochromatin.