Synthetic lethal approaches for assessing combinatorial efficacy of chemotherapeutic drugs.

摘要: The recent advances in pharmacogenomics have made personalized medicine no longer a pipedream but precise and powerful way to tailor individualized cancer treatment strategies. Cancer is devastating disease, contemporary chemotherapeutic strategies now integrate several agents the of some types cancer, with intent block more than one target simultaneously. This constitutes premise synthetic lethality, an attractive therapeutic strategy already demonstrating clinical success patients breast ovarian cancers. Synthetic lethal combinations offer potential also hitherto "undruggable" mutations that challenged field for decades. However, lethality therapy very much still its infancy, selecting most appropriate combinations-or pairs-is not always intuitive process. Here, we review progress identifying their highlight tools through which pairs are identified.