Inhibitory effects of fluoroquinolone antibiotics on Babesia divergens and Babesia microti, blood parasites of veterinary and zoonotic importance.
作者： Mohamed Abdo Rizk , Mahmoud AbouLaila , Shimaa Abd El-Sayed , Azirwan Guswanto , Naoaki Yokoyama
DOI: 10.2147/IDR.S159519
关键词: Babesia 、 Antibiotics 、 Biology 、 Enrofloxacin 、 Ofloxacin 、 Babesia divergens 、 Norfloxacin 、 Enoxacin 、 Microbiology 、 Trovafloxacin
摘要: Aim This study aimed to evaluate the inhibitory effects of fluoroquinolone antibiotics, including enrofloxacin, enoxacin, trovafloxacin, norfloxacin, and ofloxacin, on in vitro vivo growth Babesia divergens microti parasites, respectively. Materials methods The antibiotics against B. microti, respectively were evaluated using fluorescence-based assay. Additionally, combination therapies highly effective (enrofloxacin, trovafloxacin) with diminazene aceturate, luteolin, or pyronaridine tetraphosphate tested cultures divergens. Results Enrofloxacin, enoxacin most fluoroquinolones divergens, followed by norfloxacin ofloxacin. Furthermore, a trovafloxacin either significantly enhanced effect cultures. In mice infected aceturate therapy exhibited potential antibabesial effect. Conclusion These results suggest that safe cheap fluoroquinolone, such as might be used for treatment clinical cases caused spp. animals humans.
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