A possible role for insulin in the altered capability for hepatic enzyme adaptation during aging.
作者： Gerald Gold , Karen Karoly , Colette Freeman , Richard C. Adelman
DOI: 10.1016/0006-291X(76)90222-9
关键词: Insulin oscillation 、 In vitro 、 Endocrinology 、 Time course 、 Insulin 、 Internal medicine 、 Pancreatic islets 、 Biology 、 Pancreas 、 Liver enzyme 、 Period (gene)
摘要: The pattern of change in the concentration immunoreactive insulin portal vein blood during a 7-hour period following intragastric administration glucose to fasted, male Sprague-Dawley rats is modified both magnitude and time course response as rat age increases from 2- 24-months. This alteration control levels probably not consequence modifications availability administered pancreas. A similar modification secretion also evident when pancreatic islets isolated fasted donors aged 24-months are perifused with invitro. may represent first demonstration an altered aging animals which expressed same way invitro system.
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sci-hub.se 参考文章(18)
Norton Nelson, A PHOTOMETRIC ADAPTATION OF THE SOMOGYI METHOD FOR THE DETERMINATION OF GLUCOSE Journal of Biological Chemistry. ,vol. 153, pp. 375- 380 ,(1944) , 10.1016/S0021-9258(18)71980-7
Michael Somogyi, Determination of blood sugar. Journal of Biological Chemistry. ,vol. 160, pp. 69- 73 ,(1945) , 10.1016/S0021-9258(18)43098-0
Richard C. Adelman, An age-dependent modification of enzyme regulation. Journal of Biological Chemistry. ,vol. 245, pp. 1032- 1035 ,(1970) , 10.1016/S0021-9258(18)63285-5
R. C. ADELMAN, C. FREEMAN, Age-dependent regulation of glucokinase and tyrosine aminotransferase activities of rat liver in vivo by adrenal, pancreatic and pituitary hormones. Endocrinology. ,vol. 90, pp. 1551- 1560 ,(1972) , 10.1210/ENDO-90-6-1551
N. B. Ruderman, V. Lauris, Effect of Acute Insulin Deprivation on Rat Liver Glucokinase Diabetes. ,vol. 17, pp. 611- 616 ,(1968) , 10.2337/DIAB.17.10.611
Richard C. Adelman, Gary W. Britton, The Impaired Capability for Biochemical Adaptation During Aging BioScience. ,vol. 25, pp. 639- 643 ,(1975) , 10.2307/1297031
M Ahmed, Mary C Gannon, FQ Nuttall, None, Postprandial plasma glucose, insulin, glucagon and triglyceride responses to a standard diet in normal subjects Diabetologia. ,vol. 12, pp. 61- 67 ,(1976) , 10.1007/BF01221966
Gary W. Britton, Samuel Rotenberg, Richard C. Adelman, Impaired regulation of corticosterone levels during fasting in aging rats. Biochemical and Biophysical Research Communications. ,vol. 64, pp. 184- 188 ,(1975) , 10.1016/0006-291X(75)90236-3
Caleb E. Finch, Jeffrey R. Foster, Alfred E. Mirsky, Ageing and the Regulation of Cell Activities during Exposure to Cold The Journal of General Physiology. ,vol. 54, pp. 690- 712 ,(1969) , 10.1085/JGP.54.6.690
GEORGE S. ROTH, Age-related changes in specific glucocorticoid binding by steroid-responsive tissues of rats. Endocrinology. ,vol. 94, pp. 82- 90 ,(1974) , 10.1210/ENDO-94-1-82