Heterogeneous surface-modified nanoplatforms for the targeted therapy of haematological malignancies.
作者： Sanjay Kulkarni , Abhijeet Pandey , Srinivas Mutalik
DOI: 10.1016/J.DRUDIS.2019.10.001
关键词: Surface modified 、 Radiation therapy 、 Golgi apparatus 、 Aptamer 、 Genetic enhancement 、 Tumor cells 、 Chemistry 、 Targeted therapy 、 Dendritic cell 、 Cancer research
摘要: Here, we focus on nanoparticle (NP)-based platforms for the targeted therapy of haematological malignancies (HMs), providing an overview surface-modified nanoplatforms, such as aptamer-, metal-, nucleic acid-, toxin, and peptide-modified NPs, efficient targeting tumor cells. We discuss NPs subcellular compartments, including mitochondria, nucleus Golgi apparatus, enhanced HMs. also review stimuli-responsive nanoplatforms modulating site-specific release drugs. provide insight into alternative modes therapy, phototherapy, gene dendritic cell (DC) radiotherapy, highlighting recent advances in treatment
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