Hematological malignancies: disease pathophysiology of leukemic stem cells.
作者： Abhay Chowdhary , Bharathi Ramdass , Prasad S. Koka
DOI:
关键词: Hematopoietic stem cell transplantation 、 Myeloid 、 Disease 、 Haematopoiesis 、 Chemotherapy 、 Senescence 、 Immunology 、 Stem cell 、 Progenitor cell 、 Medicine
摘要: Abstract Hematopoietic homeostasis is maintained throughout the lifetime of an individual through self-renewal hematopoietic stem cells. Defects in self - renewal and differentiation lead to insufficiency development malignancies. Leukemic cells (LSCs), which are considered originate from or progenitor cells, not only adopt regulatory machinery operating normal HSCs but establish their own mechanisms against apoptosis senescence. malignancies Lymphoid origin with CLL ALL myeloid AML CML addition there disease plasma multiple myelomas. One major therapeutic strategies for hematological cell transplantation along combination chemotherapy. The review gives insight different malignancies, mechanism available at present.
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