Functional proteomic insights in B-cell chronic lymphocytic leukemia.
作者： Paula Díez , Rafael Góngora , Alberto Orfao , Manuel Fuentes
DOI: 10.1080/14789450.2017.1275967
关键词: Cell signaling 、 Immunology 、 Proteomics 、 Biology 、 B cell 、 Leukemia 、 Immunophenotyping 、 Cancer research 、 Chronic lymphocytic leukemia 、 Flow cytometry 、 Disease
摘要: B cell chronic lymphocytic leukemia (B-CLL) is a hematological malignancy considered as the most common in Western world. The understanding of differentiation crucial for diagnosis, prognosis, and treatment disease. Areas covered: In this review, B-cell ontogeny its relation with CLL development, combination proteomic approaches which could provide deep characterization disease through cellular signaling pathways involved pathological cells described. Expert commentary: Although conventional strategies (genome sequencing, morphology assays, immunophenotyping by flow cytometry and/or immunochemistry) have allowed establishment stage based on different parameters, it still necessary to utilize novel (e.g., proteomics) that potential simultaneously analyze thousands molecules improve CLL.
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