Treatment of Heart Failure with Spironolactone — Trial and Tribulations

作者: John J.V. McMurray , Eileen O'Meara

DOI: 10.1056/NEJMP048144

关键词: Renal functionSpironolactoneHeart failureSurgeryPharmacotherapyHeart diseaseInternal medicineClinical trialMedicineMEDLINE

摘要: After the release of results RALES trial, there was a striking increase in hospital admissions and deaths related to hyerkalemia. Dr. John McMurray Eileen O'Meara explain that ...

参考文章(3)
David N. Juurlink, Muhammad M. Mamdani, Douglas S. Lee, Alexander Kopp, Peter C. Austin, Andreas Laupacis, Donald A. Redelmeier, Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study The New England Journal of Medicine. ,vol. 351, pp. 543- 551 ,(2004) , 10.1056/NEJMOA040135
Bertram Pitt, Faiez Zannad, Willem J. Remme, Robert Cody, Alain Castaigne, Alfonso Perez, Jolie Palensky, Janet Wittes, The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. The New England Journal of Medicine. ,vol. 341, pp. 709- 717 ,(1999) , 10.1056/NEJM199909023411001