Brain oxidative stress--analytical chemistry and thermodynamics of glutathione and NADPH.

摘要: Oxidative stress occurs in the brain due to stroke, Parkinson's disease, Alzheimer's amyotrophic lateral sclerosis, trauma, aging and other conditions. Analysis of effects oxidative can involve quantitation GSH, GSSG, NADPH NADP. Reliable rapid assays have been developed for these compounds will be presented detail. The used analyze stress. Thermodynamic calculations performed find observed electrochemical potentials GSSG/GSH NADP/NADPH couples during biochemical consequences thermodynamic changes cell discussed as well defense mechanisms available recover from