Free radicals in brain, functions and failures
作者： Garry R. Buettner , Freya Q. Schafer , Fred E. Samson
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摘要: Free radicals, you can't live with them and without them. Appreciation is growing that free radicals related oxidants are ubiquitous they involved in common pathways lead to tissue damage from a wide variety of insults. Some combination reactive oxygen species (ROS) nitrogen (RNS) implicated an array neuro-degenerative diseases (including amyotrophic lateral sclerosis Parkinson's disease) many other human health problems ranging the toxicity some xenobiotics cataractogenesis, carcinogenesis, atherosclerosis, diabetes mellitus, ischemia/reperfusion injury, cancer, aging process itself. This has created impression all highly damaging biological systems—in short, bad. But more informed examination chemistry reveals range unique advantages may have as regulators normal physiological functions components information processing brain. Furthermore, ROS RNS biochemical properties permit role intercellular communication, operating extracellular microenvironment, "parasynaptic" manner. Nitric oxide (NO
参考文章(47)
J Adams, JD, Klaidman, LK, Chang, ML and Yang, Brain oxidative stress--analytical chemistry and thermodynamics of glutathione and NADPH. Current Topics in Medicinal Chemistry. ,vol. 1, pp. 473- 482 ,(2001) , 10.2174/1568026013394778
D R Brown, B S Wong, M S Sy, A Yin-Yang role for metals in prion disease. Panminerva Medica. ,vol. 43, pp. 283- 287 ,(2001)
Joseph S. Beckman, Jun Chen, Harry Ischiropoulos, Ling Zhu, Karl A. Conger, James H. Halsey, Nitric Oxide as a Mediator of Cerebral Blood-Flow, Synaptic Plasticity, and Superoxide-Mediated Brain Injury Birkhäuser, Boston, MA. pp. 174- 195 ,(1993) , 10.1007/978-1-4615-9840-4_10
Merrill Tarr, Fred Samson, Oxygen Free Radicals in Tissue Damage ,(2013)
Hiram F. Gilbert, Molecular and Cellular Aspects of Thiol-Disulfide Exchange Advances in Enzymology - and Related Areas of Molecular Biology. ,vol. 63, pp. 69- 172 ,(2006) , 10.1002/9780470123096.CH2
E. Head, J. Liu, T. M. Hagen, B. A. Muggenburg, N. W. Milgram, B. N. Ames, C. W. Cotman, Oxidative damage increases with age in a canine model of human brain aging Journal of Neurochemistry. ,vol. 82, pp. 375- 381 ,(2002) , 10.1046/J.1471-4159.2002.00969.X
Garry R. Buettner, Freya Q. Schafer, Steven Yue Qian, IRON AND FREE RADICAL OXIDATIONS IN CELL MEMBRANES Cellular and Molecular Biology. ,vol. 46, pp. 657- 662 ,(2000)
Math P. Cuajungco, Kyle Y. Fagét, Zinc takes the center stage: its paradoxical role in Alzheimer's disease. Brain Research Reviews. ,vol. 41, pp. 44- 56 ,(2003) , 10.1016/S0165-0173(02)00219-9
John Smythies, The neurochemical basis of learning and neurocomputation: the redox theory Behavioural Brain Research. ,vol. 99, pp. 1- 6 ,(1999) , 10.1016/S0166-4328(98)00098-9
Ashley I Bush, Metal complexing agents as therapies for Alzheimer’s disease Neurobiology of Aging. ,vol. 23, pp. 1031- 1038 ,(2002) , 10.1016/S0197-4580(02)00120-3