The insensitivity of the developing rat foetus to the toxic effects of acrylamide
作者： P.M. Edwards
DOI: 10.1016/0009-2797(76)90062-4
关键词: Physiology 、 Offspring 、 Acrylamide 、 Fetus 、 Placenta 、 Biochemistry 、 Medicine 、 Adverse effect 、 Toxicology 、 General Medicine
摘要: Abstract Acrylamide was given to pregnant rats either in a single dose or by feeding acrylamide the diet. No adverse effects were seen offspring, even at doses which produced neuropathy mothers. This insensitivity is not due failure of cross placenta.
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sci-hub.se 参考文章(13)
W. G. BRADLEY, M. H. WILLIAMS, Axoplasmic flow in axonal neuropathies. I. Axoplasmic flow in cats with toxic neuropathies. Brain. ,vol. 96, pp. 235- 246 ,(1973) , 10.1093/BRAIN/96.2.235
Richard J. Owellen, Albert H. Owens, Douglas W. Donigian, The binding of vincristine, vinblastine and colchicine to tubulin Biochemical and Biophysical Research Communications. ,vol. 47, pp. 685- 691 ,(1972) , 10.1016/0006-291X(72)90546-3
A. R. Mattocks, Spectrophotometric determination of pyrazolines and some acrylic amides and esters Analytical Chemistry. ,vol. 40, pp. 1347- 1349 ,(1968) , 10.1021/AC60264A061
John Prineas, The pathogenesis of dying-back polyneuropathies. II. An ultrastructural study of experimental acrylamide intoxication in the cat. Journal of Neuropathology and Experimental Neurology. ,vol. 28, pp. 598- 621 ,(1969) , 10.1097/00005072-196910000-00004
Philippa M. Edwards, The distribution and metabolism of acrylamide and its neurotoxic analogues in rats. Biochemical Pharmacology. ,vol. 24, pp. 1277- 1282 ,(1975) , 10.1016/0006-2952(75)90336-6
P. Banks, D. Mayor, Mary Mitchell, D. Tomlinson, Studies on the translocation of noradrenaline-containing vesicles in post-ganglionic sympathetic neuronesin vitro. Inhibition of movement by colchicine and vinblastine and evidence for the involvement of axonal microtubules The Journal of Physiology. ,vol. 216, pp. 625- 639 ,(1971) , 10.1113/JPHYSIOL.1971.SP009544
HERBERT H. SCHAUMBURG, HENRYK M. WISNIEWSKI, PETER S. SPENCER, Ultrastructural studies of the dying-back process 1. Peripheral nerve terminal and axon degeneration in systemic acrylamide intoxication Journal of Neuropathology and Experimental Neurology. ,vol. 33, pp. 260- 284 ,(1974) , 10.1097/00005072-197404000-00006
Peter S. Spencer, Herbert H. Schaumburg, A review of acrylamide neurotoxicity. Part I. Properties, uses and human exposure. Canadian Journal of Neurological Sciences. ,vol. 1, pp. 143- 150 ,(1974) , 10.1017/S0317167100019739
Peter S. Spencer, Herbert H. Schaumburg, A review of acrylamide neurotoxicity. Part II. Experimental animal neurotoxicity and pathologic mechanisms. Canadian Journal of Neurological Sciences. ,vol. 1, pp. 152- 169 ,(1974) , 10.1017/S0317167100119201
Grisham Lm, Creswell Km, Bamburg, Mizel Sb, Wilson L, Interaction of drugs with microtubule proteins. Federation proceedings. ,vol. 33, pp. 158- ,(1974)