Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors. A study of 200 cases.
作者： Jerzy Lasota , Agnieszka Wozniak , Maarit Sarlomo-Rikala , Janusz Rys , Radzislaw Kordek
DOI: 10.1016/S0002-9440(10)64623-8
关键词: Gene 、 Primary tumor 、 Proto-Oncogene Proteins c-kit 、 Mutation 、 Missense mutation 、 Exon 、 Genetics 、 Biology 、 Stromal tumor 、 Cancer research 、 Carcinogenesis
摘要: … the KIT protein. Activating mutations in the juxtamembrane domain (exon 11) of the c-kit gene … These mutations lead into ligand-independent activation of the tyrosine kinase of c-kit, and …
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