Molecular Biology and Pathology of Gastrointestinal Stromal Tumors
作者： Paul J. Zhang
DOI: 10.1007/978-1-4614-6015-2_11
关键词:
摘要: Gastrointestinal stromal tumors (GISTs) are mesenchymal of the gastrointestinal (GI) tract with characteristic histologic and molecular features. These KIT or PDFGRA mutation-driven originating from interstitial cells Cajal (ICC) their precursors, they generally express CKIT protein. GISTs most common malignant about 5,000 new cases diagnosed each year in United States.
springer.com
sci-hub.st 参考文章(130)
Jerzy Lasota, Agnieszka Wozniak, Maarit Sarlomo-Rikala, Janusz Rys, Radzislaw Kordek, Aziza Nassar, Leslie H. Sobin, Markku Miettinen, Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors. A study of 200 cases. American Journal of Pathology. ,vol. 157, pp. 1091- 1095 ,(2000) , 10.1016/S0002-9440(10)64623-8
S Lev, J Blechman, S Nishikawa, D Givol, Y Yarden, Interspecies molecular chimeras of kit help define the binding site of the stem cell factor. Molecular and Cellular Biology. ,vol. 13, pp. 2224- 2234 ,(1993) , 10.1128/MCB.13.4.2224
Markku Miettinen, Jerzy Lasota, Gastrointestinal Stromal Tumors: Review on Morphology, Molecular Pathology, Prognosis, and Differential Diagnosis Archives of Pathology & Laboratory Medicine. ,vol. 130, pp. 1466- 1478 ,(2006) , 10.1043/1543-2165(2006)130[1466:GSTROM]2.0.CO;2
Maria Debiec-Rychter, Jan Cools, Herlinde Dumez, Raf Sciot, Michel Stul, Nicole Mentens, Hilde Vranckx, Bartosz Wasag, Hans Prenen, Johannes Roesel, Anne Hagemeijer, Allan Van Oosterom, Peter Marynen, Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants Gastroenterology. ,vol. 128, pp. 270- 279 ,(2005) , 10.1053/J.GASTRO.2004.11.020
Ping Chi, Yu Chen, Lei Zhang, Xingyi Guo, John Wongvipat, Tambudzai Shamu, Jonathan A. Fletcher, Scott Dewell, Robert G. Maki, Deyou Zheng, Cristina R. Antonescu, C. David Allis, Charles L. Sawyers, ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours Nature. ,vol. 467, pp. 849- 853 ,(2010) , 10.1038/NATURE09409
Suzanne George, Sunitinib, a multitargeted tyrosine kinase inhibitor, in the management of gastrointestinal stromal tumor Current Oncology Reports. ,vol. 9, pp. 323- 327 ,(2007) , 10.1007/S11912-007-0040-1
Katherine A. Janeway, Karen H. Albritton, Annick D. Van Den Abbeele, Gina Z. D'Amato, Paolo Pedrazzoli, Salvatore Siena, Joel Picus, James E. Butrynski, Marcus Schlemmer, Michael C. Heinrich, George D. Demetri, Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib. Pediatric Blood & Cancer. ,vol. 52, pp. 767- 771 ,(2009) , 10.1002/PBC.21909
Narasimhan P. Agaram, Peter Besmer, Grace C. Wong, Tianhua Guo, Nicholas D. Socci, Robert G. Maki, Diann DeSantis, Murray F. Brennan, Samuel Singer, Ronald P. DeMatteo, Cristina R. Antonescu, Pathologic and Molecular Heterogeneity in Imatinib-Stable or Imatinib-Responsive Gastrointestinal Stromal Tumors Clinical Cancer Research. ,vol. 13, pp. 170- 181 ,(2007) , 10.1158/1078-0432.CCR-06-1508
Anette Duensing, Fabiola Medeiros, Bryna McConarty, Nora E Joseph, Dipak Panigrahy, Samuel Singer, Christopher DM Fletcher, George D Demetri, Jonathan A Fletcher, Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs) Oncogene. ,vol. 23, pp. 3999- 4006 ,(2004) , 10.1038/SJ.ONC.1207525
Stevan R. Hubbard, Juxtamembrane autoinhibition in receptor tyrosine kinases Nature Reviews Molecular Cell Biology. ,vol. 5, pp. 464- 471 ,(2004) , 10.1038/NRM1399