Epithelial (E‐) and placentae (P‐) cadherin cell adhesion molecule expression in breast carcinoma

摘要: Two members of the cadherin family intercellular adhesion molecules are found in normal breast tissue: E- (epithelial) is present both luminal and myoepithelial cells, whereas P- (placental) confined to myoepithelium. There experimental evidence that loss E-cadherin associated with increased invasiveness malignant cells vitro, which stimulated us examine presence distribution P-cadherin carcinomas by means immunohistochemical staining. E-Cadherin was all situ invasive ductal examined, although it had a patchy staining variable intensity. However, 83 per cent lobular there complete E-cauherin expression. In remaining 17 tumours, appeared have an abnormal within cytoplasm expression on cell membrane. P-Cadherin, contrast, absent from benign epithelium 25 type. It only one carcinoma We suggest cell-cell mediated plays part characteristic morphology carcinomas.