Ectopic expression of guanylyl cyclase C and endogenous ligand guanylin correlates significantly with Helicobacter pylori infection in gastric carcinogenesis
作者： Jian-Feng Zhang , Zhen-Biao Mao , Zeng-Li Li , Shi-Min Xue , Hui-Jun Zhu
DOI: 10.1007/S12032-011-0067-X
关键词: Helicobacter pylori 、 Dysplasia 、 Intestinal metaplasia 、 Cancer research 、 Gastric mucosa 、 Guanylate cyclase 2C 、 Guanylin 、 Uroguanylin 、 Gastroenterology 、 Atrophic gastritis 、 Biology 、 Internal medicine
摘要: The molecular mechanisms leading to gastric carcinogenesis still remain unclear. Recently, several studies demonstrated that over-expression of guanylyl cyclase C (GCC) has been detected in intestinal-type cancer (GC) and precursor lesions. Our objective was explore the expression levels GCC endogenous ligands guanylin (GN) uroguanylin (UGN) correlation between Helicobacter pylori (H. pylori) GCC, GN, UGN expressions patients at different stages from normal mucosa superficial gastritis, atrophic intestinal metaplasia (IM), dysplasia, finally adenocarcinoma. GN absent distal tissues gastritis all cases, whereas they were measured IM, GC. closely related From carcinomas, H. positive rate 19.7, 33.3, 69.6, 80.0, 82.1%, respectively. found Also, infection them. These results demonstrate detection will be beneficial diagnosis human carcinoma precancerous Ectopic may play an important role
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