Colloid carcinoma of the pancreas

摘要: Abstract Pancreatic colloid carcinoma, also known as mucinous non-cystic carcinoma or gelatinous is a of ductal origin, characterized morphologically by well-circumscribed pools mucin that contain detached floating epithelial elements. Its distinction from conventional adenocarcinoma important because beyond the morphological dissimilarities, there are molecular and biologic differences between ordinary pancreas. Clinically, patients with often present abdominal/epigastric pain diarrhoea. They usually have larger tumours than at presentation. Often, an associated intraductal papillary neoplasm found. Macroscopically, frequently well demarcated appearance. Microscopic examination reveals well-delineated scanty malignant cells. In contrast mixed carcinomas, which may focally exhibit similar pattern, pure carcinomas (those in most tumour composed pattern) seem to more indolent course longer survival rates adenocarcinoma. Even presence lymph node metastases, can sometimes attain prolonged survival. There certain characteristics being recognized increasingly potential reasons for its distinctive clinicopathologic attributes. One feature cells they altered cell polarity secretory activity manifested stroma-facing surfaces. addition, it seems production MUC2 type mucin, specific precursors, might act barrier limiting growth spread tumor partially explaining nature these cancers. The frequent association neoplasms observation share profile MUC1 expression suggested be different carcinogenetic pathway adenocarcinoma, believed originate pancreatic intraepithelial neoplasia.