Metabolic intervention to affect myocardial recovery following ischemia.

摘要: Myocardial recovery during reperfusion following ischemia is critical to patient survival in a broad spectrum of clinical settings. functional correlates well with myocardial adenosine triphosphate (ATP). Adenosine uniformly incomplete moderate ischemic injury and therefore subject manipulation by metabolic intervention. By definition ATP limited either (1) energy availability application the phosphorylation monophosphate (AMP) or (2) AMP for this conversion. Experimental data suggest that substrate mechanisms required its creation high phosphate bonds (AMP conversion ATP) are more than adequate injury. availability, however, inadequate due loss diffusable adenine nucleotide purine metabolites. These precursors necessary fuel salvage pathways. Metabolic interventions enhance rather those improve recommended. The various discussed framework along rationale against their application.