Clinical significance and prognostic value of serum sHER-2/neu levels in patients with solid tumors

摘要: The purpose of this study was to determine HER-2/neu in the serum patients with solid tumors and investigate its potential usefulness predicting clinical course disease. At same time, we compared ability HER-2/neu, CA15.3, CA12-5, CA19-9, carcino embryonic antigen (CEA), α-feto-protein (AFP) breast, colorectal, lung cancer patients. Forty, thirty-six, twenty-three lung, colon breast were included study, respectively. Serum levels CEA, AFP measured. Her-2 neu significantly higher groups than colorectal controls (P 0.05). There a positive correlation between CA15-3 values groups. We found 0.75(0.59–0.90) for Her-2/neu from area under curve (AUC). P-value is 0.003, discovered that 9 ng/ml best inersection point. In situation, calculated sensitivity 65.2%, specificity 100%, predictive value negative 75.8%, accuracy 83.4%. These findings indicate HER2/neu are clinically valuable monitoring metastatic non-small cell Prognosis provides an additional over commonly used test. Measurements provide prognostic information clinician can especially be Further validation needed confirm these findings.