Ultrasensitive direct impedimetric immunosensor for detection of serum HER2.

摘要: Abstract Assesment of human epidermal growth factor receptor 2 status is a key prompting definitive treatment decisions that help in reducing mortality rates associated with breast cancer. In this article, highly sensitive and low-cost impedimetric immunosensor using single-chain fragment variable antibody fragments was developed for quantitative detection from serum employing gold nanoparticle-modified disposable screen-printed carbon electrodes. The nanoparticles facilitate fast electron transfer offer biocompatible surface immobilization small an oriented manner, resulting improved antigen binding efficiency. fragment-modified screen printed exhibits wide dynamic range 0.01–100 ng mL−1 limit 0.01 ng mL−1. advantages offered by platform terms high sensitivity, broad demonstrates great potential monitoring levels the management other cancers.