Anatomical specificity of vascular endothelial growth factor expression in glioblastomas: a voxel-based mapping analysis
作者： Xing Fan , Yinyan Wang , Kai Wang , Shuai Liu , Yong Liu
DOI: 10.1007/S00234-015-1602-9
关键词: Angiogenesis 、 Voxel 、 Medicine 、 Genetic Alteration 、 Vascular endothelial growth factor 、 Neuroradiology 、 Neuroimaging 、 Pathology 、 VEGF receptors 、 Vegf expression
摘要: Introduction The expression of vascular endothelial growth factor (VEGF) is a common genetic alteration in malignant gliomas and contributes to the angiogenesis of tumors. This study aimed to investigate the anatomical specificity of VEGF expression levels in glioblastomas using voxel-based neuroimaging analysis. Methods Clinical information, MR scans, and immunohistochemistry stains of 209 patients with glioblastomas were reviewed. All tumor lesions were segmented manually and subsequently registered to standard brain …
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