Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

摘要: I. Introduction THE establishment of a vascular supply is critical requirement for cellular inflow nutrients, outflow waste products, and gas exchange in most tissues organs (1). In endocrine glands, the vascularization not only serves such needs but also provides pathway specific secretory products (2, 3). Furthermore, anterior pituitary (4–6) adrenal medulla (7, 8), an unusual angioarchitecture, where portal capillary plexus delivers venous blood originating from adjacent gland, intimately involved control activity. medulla, this design may even determine ultimate product (8). Not surprisingly, cardiovascular system first organ to develop reach functional state embryo (9–12). human, primitive vessels appear as early day 15, circulation with beating heart already established by end third week.