Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT.

作者: Carlo Bartolozzi , Francescamaria Donati , Dania Cioni , Carlo Procacci , Giovanni Morana

DOI: 10.1007/S00330-003-1966-9

关键词: Gold standard (test)Magnetic resonance imagingMulticenter trialRadiologyMedicineSpiral ctUltrasoundSpiralNeuroradiologyNuclear medicineInterventional radiology

摘要: The aim of this study was to compare unenhanced MRI, MnDPDP-enhanced and spiral CT in the detection hepatic colorectal metastases. Forty-four patients with metastases were examined MRI contrast-enhanced CT. MR examination protocol included baseline T1-weighted spin-echo (SE), gradient-recalled-echo (GRE), T2-weighted fast-SE sequences; SE GRE sequences obtained 30–60 min after administration 0.5 µmol/kg (0.5 ml/kg) mangafodipir trisodium (MnDPDP). Images interpreted by three blinded readers. Findings at compared those intraoperative US, which used as term reference. Intraoperative US detected 128 In a lesion-by-lesion analysis, overall rate 71% (91 128) for CT, 72% (92 90% (115 MRI. more sensitive than either (p<0.0001) or (p=0.0007). patient-by-patient agreement gold standard higher (33 44 cases) (22 cases, p=0.0023) (21 p=0.0013). is superior

参考文章(32)
Guy Marchal, Paul Van Hecke, Philippe Demaerel, E Decrop, C Kennis, AL Baert, E Van der Schueren, None, Detection of liver metastases with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T American Journal of Roentgenology. ,vol. 152, pp. 771- 775 ,(1989) , 10.2214/AJR.152.4.771
Johannes Scheele, Richard Stang, Annelore Altendorf-Hofmann, Martin Paul, Resection of colorectal liver metastases. World Journal of Surgery. ,vol. 19, pp. 59- 71 ,(1995) , 10.1007/BF00316981
Michael Federle, Judith Chezmar, Daniel L. Rubin, Jeffrey Weinreb, Patrick Freeny, Udo P. Schmiedl, Jeffrey J. Brown, Joseph A. Borrello, Joseph K.T. Lee, Richard C. Semelka, Robert Mattrey, Abraham H. Dachman, Sanjay Saini, Steven E. Harms, Donald G. Mitchell, Mark W. Anderson, Hollis H. Halford, William F. Bennett, Stuart W. Young, Matthew Rifkin, Spencer B. Gay, Rocco Ballerini, Paul F. Sherwin, Ronald O. Robison, Efficacy and safety of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. Multicenter phase III clinical trials. Efficacy of early imaging. Journal of Magnetic Resonance Imaging. ,vol. 12, pp. 689- 701 ,(2000) , 10.1002/1522-2586(200011)12:5<689::AID-JMRI5>3.0.CO;2-Z
Riccardo Lencioni, Francescamaria Donati, Dania Cioni, Alessandro Paolicchi, Antonio Cicorelli, Carlo Bartolozzi, Detection of colorectal liver metastases: prospective comparison of unenhanced and ferumoxides-enhanced magnetic resonance imaging at 1.5 T, dual-phase spiral CT, and spiral CT during arterial portography. Magnetic Resonance Materials in Physics Biology and Medicine. ,vol. 7, pp. 76- 87 ,(1998) , 10.1007/BF02592232
B E Van Beers, B Gallez, J Pringot, Contrast-enhanced MR imaging of the liver. Radiology. ,vol. 203, pp. 297- 306 ,(1997) , 10.1148/RADIOLOGY.203.2.9114076
Dushyant V. Sahani, Martin E. O'Malley, Sandeep Bhat, Peter F. Hahn, Sanjay Saini, Contrast-enhanced MRI of the liver with mangafodipir trisodium: imaging technique and results. Journal of Computer Assisted Tomography. ,vol. 26, pp. 216- 222 ,(2002) , 10.1097/00004728-200203000-00010
C. Bartolozzi, R. Lencioni, F. Donati, D. Cioni, Abdominal MR: liver and pancreas. European Radiology. ,vol. 9, pp. 1496- 1512 ,(1999) , 10.1007/S003300050876