Cardiac Restraint and Support Following Myocardial Infarction

摘要: Myocardial infarction occurs when blood supply to a region of the myocardium is interrupted or eliminated, leading within seconds loss active contraction in affected and minutes cardiomyocyte death. Unable contract, infarct stretches passively each time heart generates pressure, creating an immediate mechanical disadvantage and, if large, triggering cascade pathological ventricular remodeling that eventually leads failure. Therefore, variety therapies have been explored mechanically reinforce infarcted hopes improving cardiac function limiting adverse remodeling. This chapter will discuss two major strategies for support post-MI: globally restraining one both ventricles, locally reinforcing only area. Several restraint devices local reinforcement approaches are compared evaluated their ability reduce left improve following myocardial infarction. A metrics used quantify discussed, including limitations frequently functional indices. Differences efficacy between synthetic cell-seeded tissue engineered patches investigated, followed by brief discussion importance patch material properties. Finally, methods optimizing type degree presented, experimental computational approaches.