Regulative feedback in pattern formation: towards a general relativistic theory of positional information.
作者： J. Jaeger , D. Irons , N. Monk
DOI: 10.1242/DEV.018697
关键词: Process (computing) 、 Interpretation (model theory) 、 Distribution (differential geometry) 、 Space (mathematics) 、 Biology 、 Metric (mathematics) 、 Einstein 、 Classical mechanics 、 Pattern formation 、 General relativity
摘要: Positional specification by morphogen gradients is traditionally viewed as a two-step process. A gradient formed and then interpreted, providing spatial metric independent of the target tissue, similar to concept space in classical mechanics. However, formation interpretation are coupled, dynamic processes. We introduce conceptual framework for positional which cellular activity feeds back on information encoded gradients, analogous feedback between mass-energy distribution geometry space-time Einstein's general theory relativity. discuss how such relativistic (GRPI) can guide systems-level approaches pattern formation.
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