A computational framework for 3D mechanical modeling of plant morphogenesis with cellular resolution

摘要: The link between genetic regulation and the definition of form size during morphogenesis remains largely an open question in both plant animal biology. This is partially due to complexity process, involving extensive molecular networks, multiple feedbacks different scales organization physical forces operating at levels. Here we present a conceptual modeling framework aimed generating integrated understanding plants. based on biophysical properties cells, which are under high internal turgor pressure, prevented from bursting because presence rigid cell wall. To control growth, underlying networks must interfere locally with elastic and/or plastic extensibility this We model three dimensional (3D) virtual tissue, where growth depends local modulation wall mechanical pressure. shows how generated by turgor-pressure can act autonomously non-cell drive directions. use simulations explore lateral organ formation shoot apical meristem. Although scenarios lead similar shape changes, they not equivalent different, testable predictions regarding geometrical growing organs. Using flower development as example, further show limited number gene activities explain complex changes that accompany outgrowth.