Topoisomerase I-related Parameters and Camptothecin Activity in the Colon Carcinoma Cell Lines from the National Cancer Institute Anticancer Screen

摘要: Abstract Camptothecin (CPT) derivatives are a new family of anticancer agents which selective inhibitors DNA topoisomerase I (top1) and have entered clinical trials with promising results. The cellular determinants for CPT activity were studied in the seven cell lines National Cancer Institute screen. These exhibit natural differences sensitivity to can be divided into three groups, according their increasing resistance: colo205, SW620, HCT116