Rhodium-mediated insertion of CF3-substituted carbenoid into O-H: An efficient method for the synthesis of α-trifluoromethylated alkoxy- and aryloxyacetic acid derivatives
作者： Guo-qiang Shi , Zhi-yao Cao , Wei-ling Cai
DOI: 10.1016/0040-4020(95)98698-H
关键词: Molecule 、 Carbenoid 、 Yield (chemistry) 、 Rhodium 、 Chemistry 、 Organic chemistry 、 Alkoxy group 、 Medicinal chemistry 、 Diazo 、 Insertion reaction 、 Phenols
摘要: CF3-substituted diazo compound 2 undergoes a facile rhodium carbenoid mediated O-H insertion reaction with variety of alcohols and phenols to afford the title compounds in good yield. Use as synthetic precursors for other fluorinated molecules is exemplified by transformation product 3b into β, β-difluoro- α-ketoester 5 α-hydroxyketone 8.
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