2,3-dioxabicyclo[3.3.1]nonane derivatives and antimalarial pharmaceutical compositions comprising them

摘要: 2,3-Dioxabicyclo[3.3.1]nonane derivatives, carrying, at position 4, a sulfur-containing functionality selected from the group consisting of sulfonyl, sulfinyl and sulfenyl, adhered to C(4) via methylene group, represented by structural formula (A) wherein: X is hydrogen, hydroxy, alkoxy, optionally substituted alkoxy or acyloxy, aralkoxy acyloxy substitued aryloxy, M alkenyloxy, acyl aralkoxy, arylalkenyloxy, oxalyloxy di(alkyl)amino alkyl(aryl)amino, di(aralalkyl)amino carbonyloxy di(alkyl)amino, di(aralkyl)amino alkyl(aryl)amino; together represent carbon-carbon bond an oxygen atom; L hydrogen bond; either Z radical R-S(=O)n- Y wherein R alkyl alkoxycarbonyl, cycloalkyl, aryl araklkyl alkyl, halogen CF3; n 0, 1 2, are useful for prevention and/or treatment malaria.