Trioxane dimer sulfur compounds

作者: Gary H. Posner , Andrew S. Rosenthal

DOI:

关键词: ChemistrySulfurOrganic chemistryDimerTrioxane

摘要: The disclosure provides novel trioxane sulfur dimers having Formula I: methods for their preparation, pharmaceutical compositions containing these compounds, and treating cancer, proliferative disorders, and/or malaria using compounds compositions.

参考文章(6)
Kristina Borstnik, Gary H. Posner, Tanzina Labonte, Andrew J. McRiner, Ik-Hyeon Paik, Surojit Sur, Theresa A. Shapiro, Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers ,(2003)
Kristina Borstnik, Sandra Sinishtaj, Aimee R. Usera, William Anthony Maio, Lindsey Catherine Hess, Wonsuk Chang, Ikhyeon Paik, Lauren Elaine Woodard, Gary H. Posner, Astrid C. Baege, Seongho Oh, Alvin Soloman Kalinda, Andrew Scott Rosenthal, John Gaetano D'angelo, Trioxane dimers having high anticancer and long-lasting antimalarial activities ,(2006)
Gary H. Posner, Ik-Hyeon Paik, Wonsuk Chang, Kristina Borstnik, Sandra Sinishtaj, Andrew S. Rosenthal, Theresa A. Shapiro, Malaria-Infected Mice Are Cured by a Single Dose of Novel Artemisinin Derivatives Journal of Medicinal Chemistry. ,vol. 50, pp. 2516- 2519 ,(2007) , 10.1021/JM070149M
Gary H. Posner, Ik-Hyeon Paik, Surojit Sur, Andrew J. McRiner, Kristina Borstnik, Suji Xie, Theresa A. Shapiro, Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy. Journal of Medicinal Chemistry. ,vol. 46, pp. 1060- 1065 ,(2003) , 10.1021/JM020461Q
Carmen Ortiz-Mellet, Jose Manuel Garcia-Fernandez, Jian-Xin Yu, Kazimierz Chmurski, Maria Gomez-Garcia, Jacques Defaye, Novel cyclodextrin derivatives, method for the preparation thereof and use thereof for the solubilization of pharmacologically active substances ,(2004)