Particles comprising polyesteramide copolymers for drug delivery

摘要: The present invention relates to micro- or nanoparticles comprising a polyesteramide (PEA) having chemical formula described by structural (IV), Formula (IV) wherein —m+p varies from 0.9-0.1 and q 0.1 0.9 —m+p+q=1 whereby m p could be 0-n is about 5 300; (pref 50-200) —R 1 independently selected the group consisting of (C 2 -C 20 ) alkylene, alkenylene, —(R 9 —CO—O—R 10 —O—CO—R )—, —CHR 11 12 —COOCR — combinations thereof; 3 R 4 in single backbone unit p, respectively, are hydrogen, C 6 )alkyl, )alkenyl, )alkynyl, )aryl, —(CH )SH, S(CH ), —CH OH, —CH(OH)CH , NH +, NHC(═NH +)NH COOH, )COOH, —CO—NH CH —CH(CH (CH —CH—CH —, H N—(CH Ph-CH CH═C—CH HO-p-Ph-CH —CH—, Ph-NH—, NH—(CH —C—, NH—CH═N—CH═C—CH —. )alkylene, )alkenylene, alkyloxy oligoethyleneglycol bicyclic-fragments 1,4:3,6-dianhydrohexitols (III); III 7 )aryl )alkyl 8 —(CH2)4-; alkylene alkenylene. H, methyl, alkenylene at least 0.05 b a+b=1.