作者: Zaza D. Gomurashvili , William D. Turnell , Naidu Sreenivasa Chowdari , Vassil P. Vassilev
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摘要: The invention provides biodegradable, water soluble PEA, PEUR and PEU carrier polymers, which can be used to conjugate, thereby stabilize and/or solublize, bioactive agents via polar uncharged or charged groups activated ester amino contained in the building blocks that make up backbone of polymer. are released at a controlled rate determined by biodegradation polymers. highly versatile Active Polycondensation (APC) method, is mainly carried out solution mild temperatures, readily allows synthesis such polymers also as solubilizing tethers attach drugs, biologies surface constructs liposomes, particles micelles.