Neuronal differentiation promoter
作者： Hideyuki Okano , Takuya Shimazaki , Hayato Kaneda
DOI:
关键词: Neuronal differentiation 、 Messenger RNA 、 p38 mitogen-activated protein kinases 、 Transcription (biology) 、 DNA 、 Expression vector 、 Molecular biology 、 Neural stem cell 、 Nucleic acid 、 Cell biology 、 Biology
摘要: The present invention provides an agent for promoting neuronal differentiation of neural stem cells, which contains a p38 inhibitor. In addition, the method includes cultivating cells in presence Neural are gliogenic or neurogenic. inhibitor is nucleic acid hybridizes to DNA mRNA encoding under physiological conditions, thereby inhibiting transcription and/or translation thereof, expression vector acid, low molecular and like.
lens.org 参考文章(27)
Robert Georgantas, George Adrian Calin, Carlo Maria Croce, Curt I. Civin, Stem-Progenitor Cell Specific Micro-Ribonucleic Acids and Uses Thereof ,(2007)
John Jahangir Alam, Compositions and methods for treating alzheimer's disease ,(2012)
Timothy Bruno Lowinger, Uday Khire, Jeffrey Johnson, Jill E. Wood, Aniko Redman, William J. Scott, Roger A. Smith, Bernd Riedl, Jacques Dumas, Robert Sibley, Holia Hatoum-Mokdad, Inhibition of p38 kinase activity using aryl and heteroaryl substituted heterocyclic ureas ,(1998)
Timothy Bruno Lowinger, David Gunn, Uday Khire, Catherine Brennan, Jill E. Wood, Mareli Rodriguez, William J. Scott, Roger A. Smith, Tiffany Turner, Bernd Riedl, Scott Miller, Jacques Dumas, Robert Sibley, Ming Wang, Martin Osterhout, Holia Hatoum-Mokdad, Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas ,(1998)
Martin Bresciani, David O. Ramos, Semiconductor substrate having increased facture strength and method of forming the same ,(2000)
Gerald Mcmahon, Congxin Liang, Li Sun, Chung Chen Wei, Klaus Peter Hirth, Jingrong Cui, Peng Cho Tang, 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors ,(2000)
Liguo New, Yingqiu Li, Baoxue Ge, Hongyin Zhong, Jonathan Mansbridge, Kang Liu, Jiahuai Han, None, SB203580 promote EGF‐stimulated early morphological differentiation in PC12 cell through activating ERK pathway Journal of Cellular Biochemistry. ,vol. 83, pp. 585- 596 ,(2001) , 10.1002/JCB.1253
Kenichiro Sato, Makoto Hamanoue, Ken Takamatsu, Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells. Journal of Neuroscience Research. ,vol. 86, pp. 2179- 2189 ,(2008) , 10.1002/JNR.21668
Hideki Horiuchi, Tadanori Ogata, Tadao Morino, Miao Chuai, Haruyasu Yamamoto, Continuous intrathecal infusion of SB203580, a selective inhibitor of p38 mitogen-activated protein kinase, reduces the damage of hind-limb function after thoracic spinal cord injury in rat. Neuroscience Research. ,vol. 47, pp. 209- 217 ,(2003) , 10.1016/S0168-0102(03)00216-5
Se-Ran YANG, Sung-Dae CHO, Nam-Shik AHN, Ji-Won JUNG, Joon-Suk PARK, Eun-Hye JO, Jae-Woong HWANG, Ji-Youn JUNG, Tae-Yung KIM, Byoung-Su YOON, Bong-Hee LEE, Kyung-Sun KANG, Yong-Soon LEE, Role of gap junctional intercellular communication (GJIC) through p38 and ERK1/2 pathway in the differentiation of rat neuronal stem cells. Journal of Veterinary Medical Science. ,vol. 67, pp. 291- 294 ,(2005) , 10.1292/JVMS.67.291