4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors
作者： Gerald Mcmahon , Congxin Liang , Li Sun , Chung Chen Wei , Klaus Peter Hirth
DOI:
关键词: Dosage form 、 Prodrug 、 Chemistry 、 Cancer 、 Protein kinase A 、 Stereochemistry
摘要: This invention relates to 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors. Particular disclosed herein are of formula (1) pharmaceuitaclly acceptable salts, solvates, clathrates, prodrugs thereof, wherein R1, R2, R3, R4, X, Y, Z defined herein. The further pharmaceutical compositions dosage forms comprising compounds methods for the treatment and/or prevention diseases such as, but not limited to, cancer.
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