Synthesis of fused pyrido[2,3-d]pyrimidines by thermal isomerization of 4-amino-5-vinylpyrimidines
作者： Vicente Ojea , Isabel Muinelo , JoséMa Quintela
DOI: 10.1016/S0040-4020(97)10334-9
关键词: Chemistry 、 Bond formation 、 Yield (chemistry) 、 Medicinal chemistry 、 Isomerization 、 Aromatization 、 Hydrogen transfer 、 Thermal 、 Organic chemistry
摘要: Abstract 4-dialkylamino-5-(2,2-dicyanovinyl)pyrimidines 4a-c react thermally in DMSO via [1,5] hydrogen transfer followed by carbon-carbon bond formation to yield fused pyrido[2,3- d ]pyrimidines 6a-c . 4-alkylarylamino-5-(2,2-dicyanovinyl)pyrimidines 5a-c lend themselves more readily thermal electrocyclic ring-closure aromatization, give tetracyclic 7a-c
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