Amino acid profile and nitric oxide pathway in patients on continuous ambulatory peritoneal dialysis: L-arginine depletion in acute peritonitis

摘要: To gain insights into the amino acid metabolism and L-arginine-nitric oxide system, we studied 21 control continuous peritoneal dialysis (CPD) patients 13 with 15 episodes of acute peritonitis. The concentrations acids, including L-arginine, were measured in dialysate serum. data demonstrate that end-stage renal disease on CPD who have peritonitis develop L-arginine deficiency. majority bacterial increased nitric production as judged by level nitrites dialysate. recovery from is associated a decline generation. Paradoxically, there smaller subgroup these shows low nitrite levels during to ratio peritonitis, further suggesting development substrate These findings implicate conditionally essential raise questions concerning necessity supplementation.