Muscle amino acid metabolism and the control of muscle protein turnover in patients with chronic renal failure

摘要: Abstract Malnutrition is frequently observed in patients with end-stage renal disease. Studies indicate that poor nutritional status plays a major role among factors adversely affecting patient outcome. Therefore prevention and treatment of malnutrition issue. In this article the potential mechanisms for alterations muscle protein metabolism uremia are explored. has been mainly attributed to inadequate intake nutrients, superimposed illnesses, or both. However, both clinical experimental evidence show per se may affect control amino acid metabolism. Available suggests catabolic appear be distinct at different stages chronic failure require modalities treatments. Both requirements prevalence increase as disease progresses. Muscle degradation increased by metabolic acidosis, which often found uremic patients. Another relevant, but less proven cause insulin resistance. Furthermore, specific defects metabolism, resistance growth hormone, insulin-like factor 1, very low can reduce synthesis. Finally, hemodialytic procedure stimulate breakdown All these potentiate effects concurrent anorexia, physical inactivity