Lactate as an insidious metabolite due to the Warburg effect
作者： Raymond Luc , Stephanie M. Tortorella , Katherine Ververis , Tom C. Karagiannis
DOI: 10.1007/S11033-015-3859-9
关键词: Cancer 、 Phenotype 、 Cancer metabolism 、 Tumour development 、 Cancer biology 、 Endocrinology 、 Warburg effect 、 Glycolysis 、 Cancer research 、 Internal medicine 、 Biology 、 Metabolite
摘要: Although oncogenetics remains a critical component of cancer biology and therapeutic research, recent interest has been taken towards the non-genetic features tumour development progression, such as metabolism. Specifically, it observed that cells are inclined to preferentially undergo glycolysis despite presence adequate oxygen. First reported by Otto Warburg in 1920s, now termed ‘Warburg effect’, this aberrant metabolism become particular due prevalence fermentation phenotype variety cancers studied. Consequently, proven play pivotal role proliferation. As Warburg’s observations being integrated within modern paradigms review we explore lactate an insidious metabolite effect.
springer.com
sci-hub.se 参考文章(38)
M.G. Bianchi, M. Chiu, L. Ottaviani, Towards a metabolic therapy of cancer Acta Bio Medica Atenei Parmensis. ,vol. 83, pp. 168- 176 ,(2013)
Stefan Beckert, Farshid Farrahi, Rummana S. Aslam, Heinz Scheuenstuhl, Alfred Königsrainer, M. Zamirul Hussain, Thomas K. Hunt, Lactate stimulates endothelial cell migration. Wound Repair and Regeneration. ,vol. 14, pp. 321- 324 ,(2006) , 10.1111/J.1743-6109.2006.00127.X
A. J. Levine, A. M. Puzio-Kuter, The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes Science. ,vol. 330, pp. 1340- 1344 ,(2010) , 10.1126/SCIENCE.1193494
Ling Cai, Benjamin M. Sutter, Bing Li, Benjamin P. Tu, Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes Molecular Cell. ,vol. 42, pp. 426- 437 ,(2011) , 10.1016/J.MOLCEL.2011.05.004
Gloria Bonuccelli, Aristotelis Tsirigos, Diana Whitaker-Menezes, Stephanos Pavlides, Richard G. Pestell, Barbara Chiavarina, Philippe G. Frank, Neal Flomenberg, Anthony Howell, Ubaldo E. Martinez-Outschoorn, Federica Sotgia, Michael P. Lisanti, Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism Cell Cycle. ,vol. 9, pp. 3506- 3514 ,(2010) , 10.4161/CC.9.17.12731
M. L. McCully, T. A. Chau, P. Luke, P. G. Blake, J. Madrenas, Characterization of human peritoneal dendritic cell precursors and their involvement in peritonitis Clinical and Experimental Immunology. ,vol. 139, pp. 513- 525 ,(2005) , 10.1111/J.1365-2249.2005.02713.X
Kazuki N Sugahara, Toshiyuki Murai, Hitomi Nishinakamura, Hiroto Kawashima, Hideyuki Saya, Masayuki Miyasaka, None, Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44-expressing tumor cells Journal of Biological Chemistry. ,vol. 278, pp. 32259- 32265 ,(2003) , 10.1074/JBC.M300347200
F. Vegran, R. Boidot, P. Sonveaux, O. Feron, 1004 ORAL Lactate Influx and Efflux Through Monocarboxylate Transporters Bridge Cancer Cell Metabolism and Angiogenesis European Journal of Cancer. ,vol. 47, ,(2011) , 10.1016/S0959-8049(11)70647-5
H Niizeki, M Kobayashi, I Horiuchi, N Akakura, J Chen, J Wang, J-i Hamada, P Seth, H Katoh, H Watanabe, A Raz, M Hosokawa, Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells British Journal of Cancer. ,vol. 86, pp. 1914- 1919 ,(2002) , 10.1038/SJ.BJC.6600331
Andrew P. HALESTRAP, Nigel T. PRICE, The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation Biochemical Journal. ,vol. 343, pp. 281- 299 ,(1999) , 10.1042/BJ3430281